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目的评价抗突变型瓜氨酸化波形蛋自(MCV)抗体在类风湿关节炎(RA)诊断中的价值。方法检测136例RA患者,80例其他结缔组织病患者以及19名正常对照血清中抗MCV抗体的分布,比较抗MCV抗体与类风湿因子(RF)、抗环瓜氨酸肽(cCP)抗体和抗角蛋白抗体(AKA)的相关性,并分析上述抗体在RA诊断中的意义。结果136例RA患者抗MCV抗体敏感性和特异性分别为95.6%和80.8%,与非RA对照组比较差异有统计学意义(P<0.05)。抗MCV抗体与抗CCP抗体、AKA和RF的重叠阳性率分别为91.9%、52.8%和76.5%。经统计学分析,抗MCV抗体与抗CCP抗体、AKA和RF之间存在相关性。结论抗MCV抗体对RA有较高的诊断价值,可视为RA新的血清学诊断指标,能提高RA的早期诊断率。
Objective To evaluate the value of anti-mutant citrullinated vimentin (MCV) antibody in the diagnosis of rheumatoid arthritis (RA). Methods The distribution of anti-MCV antibodies in serum of 136 patients with RA, 80 patients with other connective tissue diseases and 19 normal controls were detected. The anti-MCV antibodies against rheumatoid arthritis (RF), anti-cyclic citrullinated peptide (cCP) Anti-keratin antibodies (AKA), and to analyze the significance of these antibodies in the diagnosis of RA. Results The sensitivity and specificity of anti-MCV antibodies in 136 patients with RA were 95.6% and 80.8%, respectively, which were significantly different from those in non-RA patients (P <0.05). The overlapping positive rates of anti-MCV antibody and anti-CCP antibody, AKA and RF were 91.9%, 52.8% and 76.5% respectively. Statistically, there was a correlation between anti-MCV antibodies and anti-CCP antibodies, AKA and RF. Conclusion Anti-MCV antibodies have high diagnostic value for RA and can be regarded as a new serological diagnostic index of RA, which can improve the early diagnosis rate of RA.