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目的:研究窒息对新生儿胃电活动的影响。方法:研究对象来自我院1998年9月～2000年5月以窒息收住新生儿病房的足月新生儿32例,其中重度窒息20例,轻度窒息12例。对照组:系同期以新生儿生理性黄疸收住院的足月新生儿10例,无消化道症状,吃奶好,二便正常。采用瑞典Synectics公司生产的便携式Digitrapper双电极EGG记录仪进行胃电图检查,用计算机运行频谱分析数据。结果:窒息组与对照组比较,餐前胃动过缓显著增加,正常节律百分比、胃动过速明显降低,差别有显著意义(P<0.01和P<0.05)。餐后胃动过缓也有增加,差别有显著意义(P<0.01)。餐后正常节律百分比、胃动过速也有降低但差别无显著性意义。重度窒息组与轻度窒息组比较,前者餐前胃动过缓明显增加,正常节律百分比明显降低,差别有显著意义(P<0.01)。两者餐前胃动过速及餐后各项指标比较均无显著差异(P>0.05)。结论:(1)窒息新生儿存在明显胃电节律紊乱。临床多表现为拒奶、喂养不耐受。呕吐和腹胀等消化道症状;(2)体表胃电图与胃肌电活动的相关性较好,可用来研究窒息新生儿的胃电活动,进而研究新生儿消化道动力;(3)窒息组胃电提示异常者,曾试用普瑞博思0.2mg/(kg·次)治疗能改善临床症状,但尚缺乏胃电图观察,有待进一步胃电图研究。
Objective: To study the effect of asphyxia on neonatal gastric electrical activity. Methods: The subjects were from our hospital from September 1998 to May 2000 asphyxiation neonatal wards admitted to full-term neonatal 32 cases, of which 20 cases of severe asphyxia, mild asphyxia in 12 cases. Control group: Department of neonatal jaundice in the same period admitted to hospital full-term newborns in 10 cases, no gastrointestinal symptoms, good feeding, and two will be normal. Gastrographs were performed using a portable Digitrapper two-electrode EGG recorder manufactured by Synectics, Sweden, and the computer was used to run spectral analysis data. Results: Compared with the control group, the asphyxia group had significantly increased gastric motility, the percentage of normal rhythm and the rate of gastric tachycardia significantly decreased (P <0.01 and P <0.05). Postprandial gastric motility also increased, the difference was significant (P <0.01). Postprandial normal rhythm percentage, gastric motility also decreased but the difference was not significant. Severe asphyxia group and mild asphyxia group, the former was significantly increased gastric anorexia, the percentage of normal rhythm was significantly lower, the difference was significant (P <0.01). Both pre-stomach tachycardia and postprandial indicators were no significant difference (P> 0.05). Conclusion: (1) neonatal asphyxia obvious gastric electrical rhythm disorders. Clinical manifestations of refusal to milk, feeding intolerance. Vomiting and abdominal distension and other gastrointestinal symptoms; (2) the relationship between the body surface electrogastrogram and gastric myoelectrical activity is good, can be used to study the gastric electrical activity of asphyxia neonates, and then study the neonatal gastrointestinal motility; (3) Asphyxia Gastric abnormalities prompted group who had tried pregabalin 0.2mg / (kg · times) treatment can improve clinical symptoms, but still lack of EGG observation, pending further EGG.