目的　探讨饮食生活习惯与中年妇女胆石症的关系。方法　采用 1∶1配对病例对照研究方法 ,对 112例胆石症患者和对照组进行了调查 ,并对研究因素进行了单因素和多因素的统计分析。结果　单因素分析显示锻炼、吃早餐、主食、每顿饭量、就寝时间、牛奶和豆制品摄入与中年妇女胆石症有关 ;多因素分析结果提示吃早餐、锻炼、喝牛奶、晚餐菜谱以荤菜为主、2 2点以后就寝是中年妇女胆石症的保护因素 ;饮酒、吸烟与该症无关。结论　中年妇女应注意饮食习惯 ,以降低发生胆石症的危险。 Objective To investigate the relationship between dietary habits and cholelithiasis in middle-aged women. Methods 1: 1 matched case-control study was used to investigate 112 patients with cholelithiasis and control group, and single and multi-factor statistical analysis of the research factors. Results Univariate analysis showed that the intake of exercise, breakfast, staple food, mealtime, bedtime, milk and soy products were related to cholelithiasis of middle-aged women. Multivariate analysis suggested eating breakfast, exercising and drinking milk. Mainly after 2 2 o’clock bedtime is the protection of middle-aged women cholelithiasis; drinking, smoking has nothing to do with the disease. Conclusion Middle-aged women should pay attention to eating habits to reduce the risk of cholelithiasis.