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目的探讨E-cadherin和Vimentin在前列腺癌中的表达及其临床意义;方法回顾性分析50例前列腺癌临床资料,通过免疫组化方法检测E-cadherin和Vimentin的表达,分析前列腺癌上皮细胞E-cadherin和Vimentin的表达水平与临床分期、Gleason评分及患者术后生存率的关系;结果 E-cadherin在正常组织前列腺组织和前列腺癌上皮组织中表达阳性率分别为90%和54%(P<0.05);Vimentin在正常前列腺上皮组织和癌性上皮组织中阳性率分别为20%和160%(P<0.05),E-cadherin和Vimentin在正常前列腺组织及前列腺癌组织中表达具有统计学意义(P<0.05),而且E-cadherin和Vimentin在前列腺癌上皮细胞中表达水平与前列腺癌临床分期、Gleason评分及生存率密切相关(P<0.05)。结论前列腺癌上皮细胞E-eadherin和Vimentin表达水平与前列腺癌临床分期、Gleason评分及生存率密切相关,检测E-eadherin和Vimentin的表达有可能成为判断前列腺癌恶性程度及预后指标。
Objective To investigate the expression and clinical significance of E-cadherin and Vimentin in prostate cancer. Methods The clinical data of 50 cases of prostate cancer were retrospectively analyzed. The expressions of E-cadherin and Vimentin were detected by immunohistochemical method. The expressions of E- cadherin and Vimentin expression levels and clinical stage, Gleason score and postoperative survival rate; the positive rate of E-cadherin expression in normal tissue and prostate cancer epithelial tissues were 90% and 54% (P <0.05 ). The positive rates of Vimentin in normal prostatic epithelium and cancerous epithelium were 20% and 160%, respectively (P <0.05). The expressions of E-cadherin and Vimentin in normal prostate tissue and prostate cancer tissues were statistically significant (P <0.05). The expression of E-cadherin and Vimentin in prostate cancer epithelial cells was closely related to the clinical stage, Gleason score and survival rate of prostate cancer (P <0.05). Conclusions The expression of E-cadherin and vimentin in prostate cancer epithelial cells is closely related to the clinical stage, Gleason score and survival rate of prostate cancer. Detecting the expression of E-cadherin and Vimentin may be the marker of malignancy and prognosis of prostate cancer.