目的:观察射频热凝(RFTC)联合脉冲射频(PRF)治疗腰椎间盘突出症(LDH)的疗效及对患者血清白细胞介素8(IL-8)、趋化因子10(CXCL10)水平的影响。方法:将2014年7月至2017年5月武汉市汉阳医院收治的LDH患者60例按照随机数字表法分为联合组、PRF组各30例。联合组给予RFTC联合PRF治疗，PRF组给予单纯PRF治疗。在治疗前、治疗后7 d、治疗后3个月分别对两组患者进行视觉模拟评分(VAS)、日本骨科学会(JOA)疗效评分、Oswestry功能障碍指数(ODI)评定，同时观察患者血清IL-8、CXCL10水平变化。结果:两组患者治疗后VAS评分均降低(n t＝12.14、27.85，均n P<0.05)，JOA评分均升高(PRF组：n t＝5.329、7.576，均n P<0.05；联合组：n t＝5.980、9.526，均n P<0.05)，ODI指数均降低(PRF组：n t＝4.932、7.414，均n P<0.05；联合组：n t＝4.235、9.706，均n P<0.05)；治疗后3个月，两组患者VAS评分、JOA评分、ODI指数差异均有统计学意义，联合组均优于PRF组(n t＝7.329、5.719、2.255，均n P<0.05)。较治疗前相比，治疗后两组患者血清IL-8水平均下降(PRF组：n t＝3.621、4.631，均n P<0.05；联合组：n t＝3.393、5.370，均n P<0.05)，CXCL10浓度均升高(n t＝2.251、3.559，均n P<0.05；联合组，n t＝3.393、5.370，均n P<0.05)，且治疗后3个月联合组IL-8、CXCL10水平的调控明显优于PRF组(n t＝20.258、2.237，均n P<0.05)。n 结论:RFTC联合PRF治疗LDH效果较好，能明显缓解临床症状，减轻炎性反应，作用持久。“,”Objective:To observe the effect of radiofrequency thermocoagulation (RFTC) combined with pulsed radiofrequency (PRF) therapy on lumbar disc herniation (LDH) and the impacts on serum interleukin-8 (IL-8), CXC chemokine ligand 10 (CXCL10).Methods:From July 2014 to May 2017, 60 patients with LDH were randomly divided into two groups according to the random digital table method, with 30 patients in each group.The combination group was given RFTC combined with PRF therapy, while the PRF group was given single foraminal nerve PRF therapy.The visual analogue scale (VAS), the curative effect score of Japanese Orthopaedic Association (JOA) and Oswestry disability index (ODI) were assessed in the two groups before treatment, 7 days after treatment and 3 months after treatment.The serum levels of IL-8, CXCL10 were determined simultaneously.Results:After treatment, the VAS score and ODI in the two groups were decreased(VAS score: n t=12.14, 27.85, all n P<0.05; ODI: PRF groupn t=4.932, 7.414, all n P<0.05; combination groupn t=4.235, 9.706, all n P<0.05), and the JOA scores increased(PRF group:n t=5.329, 7.576, all n P<0.05; combination group:n t=5.980, 9.526, all n P<0.05). There were statistically significant differences in VAS score, JOA score and ODI between the two groups at 3 months after treatment(n t=7.329, 5.719, 2.255, all n P<0.05), which of the combination group after treatmentwere superior to the PRF group (alln P<0.05). The serum levels of IL-8 in the two groups after treatment were decreased (PRF group:n t=3.621, 4.631, all n P<0.05; combination group:n t=3.393, 5.370, all n P<0.05), and the CXCL10 levels in the two groups after treatment were increased(PRF group:n t=2.251, 3.559, all n P<0.05; combination group:n t=3.393, 5.370, all n P<0.05). There were statistically significant differences in IL-8, CXCL10 levels between the two groups at 3 months after treatment, and the regulation of IL-8 and CXCL10 levels in the combination group was significantly better than those in the PRF group (n t=20258, 2.237, all n P<0.05).n Conclusion:RFTC combined with PRF is effective in the treatment of LDH, which can significantly relieve the clinical symptoms, reduce the inflammatory response and has a lasting efficacy.