论文部分内容阅读
目的观察丹红(倍通)注射液的急慢性毒性,对其进行安全性评价。方法小鼠连续7 d静脉给药,测定药物的半数致死量(LD50)。大鼠连续给药90 d后,处死大部动物,取血,做血常规、血液生化指标测定,取主要脏器称重进行病理学检查。余下大鼠在停药继续喂养2周后,处死进行病理组织学检查。结果小鼠LD50为39.5ml/kg。各实验组大鼠在体质量增加、器官系数、血常规、血液生化指标上基本相似,与对照组比较差异无统计学意义(P>0.05)。主要脏器的病理组织学检查未见明显异常。结论急慢性毒性实验的结果表明该药安全可靠。
Objective To observe the acute and chronic toxicity of Danhong injection and evaluate its safety. Methods The mice were intravenously administered for 7 days and the median lethal dose (LD50) was determined. After 90 days continuous administration of the rats, most of the animals were sacrificed, blood was taken, and blood routines and blood biochemical indexes were measured. Main organs were weighed for pathological examination. The remaining rats were sacrificed for 2 weeks after the drug was discontinued and were sacrificed for histopathological examination. Results The mouse LD50 was 39.5 ml/kg. The rats in each experimental group were similar in body mass, organ coefficient, blood routine, and blood biochemical index, and there was no significant difference compared with the control group (P>0.05). Histopathological examination of major organs showed no obvious abnormalities. Conclusion The results of acute and chronic toxicity experiments show that the drug is safe and reliable.