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建立了液相色谱质谱法(LC-MS/MS)测定饮用水中4-叔丁基苯酚含量的方法。试样经HLB固相萃取柱富集,叔丁基醚萃取洗脱,丹酰氯衍生化后,采用BEH C18色谱柱分离,三重四级杆质谱仪测定,外标法定量。结果表明:4-叔丁基苯酚在0.5~50.0 ng/m L范围内,具有良好的线性关系,相关系数R2为0.999 8;方法检出限为0.1 ng/m L;加标回收率为85.3%~97.4%,相对标准偏差为0.9%~5.5%。该方法检出限低,准确度高,精密度好。
A method for the determination of 4-tert-butylphenol in drinking water by liquid chromatography-mass spectrometry (LC-MS / MS) was established. The sample was enriched by HLB solid phase extraction column, eluted with tert-butyl ether, derivatized with dansyl chloride, separated by BEH C18 column, determined by triple quadrupole mass spectrometer and quantified by external standard method. The results showed that 4-tert-butylphenol had a good linearity in the range of 0.5-50.0 ng / mL, with a correlation coefficient R2 of 0.999 8 and a detection limit of 0.1 ng / mL. The spiked recoveries were 85.3 % ~ 97.4%, relative standard deviation of 0.9% ~ 5.5%. The method of low detection limit, high accuracy, good precision.