目的 :了解感冒通片 (GMT)滥用所致不良反应 (ADRs)的情况 ,找出原因 ,提出预防方法。方法 :以《中国药学文摘》1 990 .1～1 999.1 2共 1 0年发表有关 GMT所致 ADRs文摘为线索检原刊文献 ,收集滥用病例 ,按设定标准进行统计分析。结果 :收集滥用 GMT病例2 46例。其中男性 1 6 5例 ,女性 6 5例 ;<1 8a:2 1 8例 ;1 8a～ 6 0 a:1 8例 ;>6 0 a:1 0例。在 2 46例反应中 :血尿 1 92例 ,血小板减少症 1 5例 ,消化道出血 1 4例 ,死亡 9例 ,紫癜 6例 ,肾衰和Stevens— Johnson综合征各 2例 ,哮喘、溶血、肝功能异常、休克、耳聋、脑水肿各 1例。滥用 :以儿童为主 (88.6 2 90 )。主要原因是 :偷食 ,儿童剂量不清、治病心切 ,擅自加大剂量或延长使用等。应加大宣传力度 ,产品进行改进 ,防止儿童偷食等 OBJECTIVE: To understand the adverse drug reactions (ADRs) caused by GMT, to find out the reasons and to put forward the preventive measures. Methods: A total of 1090 ADRs abstracts caused by GMTs were published in Chinese Medical Abstracts 1 990.1-1999.1 2 as clues, and the cases of abuse were collected and statistically analyzed according to the set standards. Results: Two 466 cases of abuse of GMT were collected. There were 165 males and 65 females; <1 8 a: 218 cases; 1 8 a ~ 6 0 a: 18 cases;> 6 0 a: 1 0 cases. In 246 cases, there were 1 92 hematuria cases, 15 thrombocytopenia cases, 14 gastrointestinal bleeding cases, 9 deaths, 6 purpura cases, 2 cases of renal failure and Stevens-Johnson syndrome, 2 cases of asthma, hemolysis, Liver dysfunction, shock, deafness, cerebral edema in 1 case. Abuse: Child-based (88.6 2 90). The main reason is: stealing food, children’s dose is not clear, eager to cure, without authorization to increase the dose or extend the use of such. Should step up publicity, product improvement, to prevent children stealing food