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目的观察善宁联合泮托拉唑治疗肝硬化门脉高压合并上消化道出血的临床疗效。方法将我院2007年12月-2010年12月收治的96例肝硬化门脉高压合并上消化道出血患者随机分成两组,治疗组48例给予善宁联合泮托拉唑治疗,对照组48例则给予垂体后叶素联合泮托拉唑治疗,两组疗程均为3-5d,1个疗程结束后比较两组的临床疗效和不良反应。结果治疗组的总有效率93.8%,对照组的总有效率79.2%,两组总有效率相比较有显著性差异(P<0.05)。结论善宁联合泮托拉唑治疗肝硬化门脉高压合并上消化道出血疗效显著,且不良反应较少,值得临床上推广。
Objective To observe the clinical efficacy of Shanning combined with pantoprazole in the treatment of patients with cirrhosis and portal hypertension combined with upper gastrointestinal bleeding. Methods 96 cases of cirrhosis with portal hypertension combined with upper gastrointestinal bleeding in our hospital from December 2007 to December 2010 were randomly divided into two groups. 48 cases in the treatment group were treated with Shannon combined with pantoprazole, and the control group 48 Cases were given pituitrin combined with pantoprazole treatment, two courses of treatment are 3-5d, after a course of treatment were compared two groups of clinical efficacy and adverse reactions. Results The total effective rate was 93.8% in the treatment group and 79.2% in the control group. The total effective rate was significantly different between the two groups (P <0.05). Conclusion The combination of pranoprazole and pranoprazole is effective in treating cirrhotic portal hypertension combined with upper gastrointestinal bleeding and has fewer side effects. It is worthy of clinical promotion.