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目的:检测大肠癌组织Survivin和环氧化酶(Cox-2)的表达情况,并探讨二者之间的相关性. 方法:应用免疫组织化学(S-P)方法分别检测Survivin和Cox-2在40例大肠癌及34例正常大肠黏膜中的表达情况. 结果:Survivin的阳性表达定位于细胞质,在大肠癌组织中其阳性率为67.5%,正常大肠黏膜组织中阳性率为0, 二者差异十分显著(P<0.01);Cox-2的阳性表达定位于细胞质,在大肠癌组织中其阳性率为90%,正常大肠黏膜组织中阳性率为11.8%,二者差异十分显著(P<0.01).Survivin 和Cox-2的表达具有一定的相关性(r=0.39,P<0.05). 结论:大肠癌组织中Survivin过表达可能是最终导致大肠癌发生的突破点,Survivin和Cox-2的协同表达表明大肠癌中的抑制凋亡是通过多种通路实现的.
OBJECTIVE: To detect the expression of Survivin and cyclooxygenase (Cox-2) in colorectal carcinoma and to explore the correlation between them.Methods: Survivin and Cox-2 were detected by immunohistochemistry (SP) Cases of colorectal cancer and 34 cases of normal colorectal mucosa.Results: The positive expression of Survivin located in the cytoplasm, the positive rate was 67.5% in colorectal cancer, normal colorectal mucosa was 0, the difference between the two is very (P <0.01). The positive expression of Cox-2 was localized in the cytoplasm. The positive rate of Cox-2 in colorectal carcinoma was 90% and that in normal colorectal mucosa was 11.8% (R = 0.39, P <0.05) .Conclusion: Overexpression of Survivin in colorectal cancer may be the breakthrough point which eventually leads to the occurrence of colorectal cancer. Survivin and Cox-2 are synergistic Expression indicates that inhibition of apoptosis in colorectal cancer is achieved through multiple pathways.