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目的分析妊娠合并甲亢患者的妊娠结局,为保障母婴安全制定措施。方法回顾性分析2000—2011年确诊的妊娠合并甲亢患者40例(35例孕前确诊,5例孕期确诊);另选择同期妊娠无合并症的50例为对照,比较妊娠结局。结果病例组先兆早产发生率12.5%,子痫前期发生率10.0%,胎儿窘迫发生率15.0%,均比对照组高,住院费用和住院天数也比对照组高;病例组中规则治疗组产科合并症较少,新生儿体重较高。结论妊娠合并甲状腺功能亢进直接影响母婴预后,应以药物治疗为主,同时定期复查血FT3、FT4和TSH的变化,及时调整用药剂量,适当增加产检次数,及时发现产科并发症并及早处理。
Objective To analyze the pregnancy outcome of pregnant women with hyperthyroidism and to make measures to ensure the safety of mother and infant. Methods Forty patients with hyperthyroidism diagnosed during pregnancy from 2000 to 2011 were retrospectively analyzed (35 cases were diagnosed before pregnancy and 5 cases were diagnosed during pregnancy). Fifty cases without complications of pregnancy were selected as controls to compare pregnancy outcomes. Results In the case group, the incidence of threatened preterm birth was 12.5%, the incidence of preeclampsia was 10.0% and the incidence of fetal distress was 15.0%, which was higher than that of the control group. The cost of hospitalization and days of hospitalization were also higher than those of the control group. Less disease, high birth weight. Conclusion Pregnancy complicated with hyperthyroidism directly affects the prognosis of maternal and infant. Drug treatment should be the mainstay. The changes of blood FT3, FT4 and TSH should be regularly reviewed. The dosage should be adjusted in time and the number of births should be appropriately increased. Obstetric complications should be detected and treated as soon as possible.