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泛素(Ubiquitin,Ub)是在真核生物中普遍存在的一种高度保守性蛋白质,主要通过泛素-蛋白酶体途径(Ubiquitin proteasome pathway,UPP)参与细胞的多种生理过程,如细胞周期的调控,转录的调节,凋亡的发生及抗原提呈等,进而促进或抑制肿瘤的发生发展。研究证实,细胞周期紊乱是妇科恶性肿瘤的重要作用机制之一。泛素对妇科恶性肿瘤的影响,受到越来越广泛的关注。对泛素在妇科恶性肿瘤方面的进一步研究,可以为妇科恶性肿瘤的早期发现、诊断、治疗和预后提供进一步清晰的方向。
Ubiquitin (Ub) is a highly conserved protein that is ubiquitous in eukaryotes and participates in various physiological processes of the cell mainly through the ubiquitin proteasome pathway (UPP), such as cell cycle Regulation, transcription regulation, the occurrence of apoptosis and antigen presentation, etc., thereby promoting or inhibiting the occurrence and development of tumors. Studies have confirmed that cell cycle disorders is one of the important mechanisms of gynecological malignancies. Ubiquitin on the impact of gynecological malignancies, by more and more attention. Further research on ubiquitin in gynecologic malignancies may provide a clearer direction for the early detection, diagnosis, treatment and prognosis of gynecological malignancies.