通过尿素均匀沉淀法合成了荧光磁性Fe_3O_4@Gd_2O_3∶Eu~(3+)纳米空心球,并且设计了一种壳-壳结构。利用模板法合成的这种壳-壳结构很好地避免了磁性纳米粒子的凝聚。扫描电子显微镜(SEM)和透射电子显微镜(TEM)测试结果表明,得到的Fe_3O_4@Gd_2O_3∶Eu~(3+)空心球直径均约为390 nm,并且磁性层和荧光层的厚度分别约55 nm和15 nm。壳的厚度和空心纳米球的尺寸可以很容易地通过调整原料的浓度和氧化硅模板的尺寸来控制。所制备的Fe_3O_4@Gd_2O_3∶Eu~(3+)空心球表现出较高的饱和磁化强度(17.1 emu/g),在紫外线的激发下发出较强的红光。这种特征使它完全可以应用于靶向治疗、免疫检测、磁性分离、荧光追踪等方面。该合成路线对其他多功能纳米空心球的可控合成也具有重要的意义。 Fluorescent magnetic Fe_3O_4 @ Gd_2O_3:Eu ~ (3+) hollow nanospheres were synthesized by homogeneous precipitation of urea and a shell-shell structure was designed. The shell-shell structure synthesized by the template method well avoids the agglomeration of the magnetic nanoparticles. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) results show that the diameter of Fe 3 O 4 @ Gd 2 O 3: Eu 3+ hollow spheres is about 390 nm, and the thickness of the magnetic and fluorescent layers are about 55 nm And 15 nm. The thickness of the shell and the size of the hollow nanosphere can be easily controlled by adjusting the concentration of the feedstock and the size of the silica template. The prepared Fe 3 O 4 @ Gd 2 O 3: Eu 3+ hollow spheres showed higher saturation magnetization (17.1 emu / g) and stronger red light upon UV excitation. This feature makes it fully applicable to targeted therapy, immune detection, magnetic separation, fluorescence tracking and so on. The synthetic route is also of great significance to the controllable synthesis of other multi-functional hollow nanospheres.