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目的分析深圳市神经梅毒患者的临床特点和生活质量,为神经梅毒的防治提供理论依据。方法采用回顾性病例分析和患者生活质量电话随访方法,了解深圳市2009—2014年神经梅毒患者的临床特点指标和生活质量情况,并进行相关分析。结果梅毒患者的生活质量无神经症状患者比有神经症状的患者好(OR=5.25),与CT异常相关(r=0.346),神经梅毒的患者脑脊液滴度与血液滴度呈负相关(r=-0.311),脑脊液中蛋白和白细胞存在正相关(r=0.369)。生活质量与脑脊液滴度、神经梅毒的分类的相关与回归无统计学意义。结论患者的生活质量与神经症状、CT异常有关,可通过改善上述因素来改善患者的生活质量,血清学滴度、脑脊液滴度无法反映神经梅毒的严重程度。
Objective To analyze the clinical features and quality of life of patients with neurosyphilis in Shenzhen and provide theoretical basis for the prevention and treatment of neurosyphilis. Methods Retrospective case analysis and quality of life telephone follow-up were used to understand the clinical features and quality of life of patients with neurosyphilis in Shenzhen from 2009 to 2014. The correlation analysis was conducted. Results The quality of life of syphilis patients with neurological symptoms was better than those with neurological symptoms (OR = 5.25), the CT abnormalities (r = 0.346), cerebrospinal fluid titers of patients with neurosyphilis were negatively correlated with the blood titers (r = -0.311), there was a positive correlation between CSF and white blood cells (r = 0.369). Quality of life and cerebrospinal fluid titer, classification and correlation of neurosyphilis no statistically significant. Conclusion The quality of life of patients is related to neurological symptoms and CT abnormalities. Patients’ quality of life can be improved by improving the above factors. Serological titers and cerebrospinal fluid titers can not reflect the severity of neurosyphilis.