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目的探析尾型同源盒转录因子-2(Caudal type homeobox transcription factor-2,CDX2)在喉癌(laryngeal carcinoma,LC)组织中的表达及其作用。方法采用免疫组织化学方法(Immunohistochemistry,IHC)检测两种组织中CDX2蛋白的表达,比较喉癌与声带息肉组织中CDX2面密度值及其积分光密度值的变化。结果 CDX2蛋白呈棕黄色颗粒,主要表达位于细胞核。对照组CDX2的表达无论在强度或细胞数量上均高于实验组,二组间差异有统计学意义(P<0.01)。结论 CDX2在喉癌组织中表达异常,CDX2异常表达可能在喉癌发生发展过程中发挥重要作用。
Objective To investigate the expression of Caudal homeobox transcription factor-2 (CDX2) in laryngeal carcinoma (LC) and its role. Methods Immunocytochemistry (IHC) was used to detect the expression of CDX2 in both tissues. The changes of CDX2 density and integral optical density in laryngeal carcinoma and vocal cord polyps were compared. Results The CDX2 protein was brownish yellow and mainly expressed in the nucleus. The expression of CDX2 in the control group was higher than that in the experimental group in terms of intensity or cell number, the difference was statistically significant (P <0.01). Conclusion The expression of CDX2 in laryngeal carcinoma is abnormal. The abnormal expression of CDX2 may play an important role in the development of laryngeal carcinoma.