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目的探讨老年多器官功能衰竭(MOFE)患者发病危险因素。方法采用1∶3配比病例对照研究方法。共纳入MOFE患者153例,以年龄(±5岁)、性别、居住地、就诊时间(±1个月)为配比条件,选取对照459例。OR值及其95%CI的计算采用条件logistic回归分析方法。结果 MOFE发病危险因素,经过多因素条件logistic回归模型拟合结果表明,免疫功能低下、肠道营养摄入障碍、感染、电解质紊乱、心律失常、心肌缺血发作、出血性脑卒中、低蛋白血症等8个因素进入模型,其OR(95%CI)分别为4.45(1.42～13.94)、5.34(1.47～19.41)、10.87(3.40～34.97)、33.42(4.7～237.63)、5.31(1.72～16.43)、3.89(1.28～11.85)、50.00(2.86～874.46)、9.31(1.30～66.49),此8个因素为MOFE发生的重要危险因素(P<0.026～0.001)。结论对有上述因素的老年人群应视为MOFE高危对象,重点防范,并控制重要危险因素。
Objective To explore the risk factors of senile multiple organ failure (MOFE). Methods 1: 3 ratio of case-control study. A total of 153 patients with MOFE were enrolled, and 459 control subjects were selected according to the age (± 5 years), sex, place of residence and visiting time (± 1 month). OR values and 95% CI were calculated using conditional logistic regression analysis. Results The risk factors for MOFE were tested by multivariate conditional logistic regression model. The results showed that immunocompromised patients suffered from impaired intestinal nutrition, infection, electrolyte imbalance, arrhythmia, myocardial ischemia, hemorrhagic stroke, hypoproteinemia The OR (95% CI) of the patients entered into the model were 4.45 (1.42-13.94), 5.34 (1.47-19.41), 10.87 (3.40-34.97), 33.42 (4.7-237.63) and 5.31 (1.72-16.43 ), 3.89 (1.28 ~ 11.85), 50.00 (2.86 ~ 874.46), 9.31 (1.30 ~ 66.49). These 8 factors were the important risk factors of MOFE (P <0.026 ~ 0.001). CONCLUSIONS: Elderly people with the above factors should be regarded as high risk MOFE targets with emphasis on prevention and control of important risk factors.