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目的观察CT引导下肝癌直接注入吡柔比星(THP)的临床疗效。方法本组16例,经CT引导下肝穿刺,吡柔比星50~70 mg/m2,生理盐水稀释至10~30 m l,瘤体内直接注入,每3周一次,3次为一疗程,共计95例次。结果部分缓解(PR)10例,稳定(NC)2例,恶化(PD)4例,有效率(RR)为62.5%。10例肝区胀痛治疗后,6例完全消失,2例明显缓解,2例无明显变化。11例AFP阳性,恢复正常4例,2例明显下降,5例无变化。影像学改变:瘤体缩小,密度强弱不均,瘤体中见液化区。组织学变化:肿瘤组织液化坏死,癌细胞变性,血管闭塞,不同程度纤维组织增生。本组患者毒副反应轻,无严重不良反应。结论CT引导下肝癌介入治疗方法简便、安全;吡柔比星治疗肝癌疗效显著,毒副作用轻。
Objective To observe the clinical efficacy of CT-guided direct injection of pirarubicin (THP). Methods The group of 16 patients undergoing liver biopsy under CT guidance, pirarubicin 50 ~ 70 mg / m2, diluted to 10 ~ 30 ml with saline, injected directly into the tumor, once every 3 weeks, 3 times for a course of treatment, total 95 cases. Results There were 10 cases of partial remission (PR), 2 cases of stable (NC) and 4 cases of deterioration (PD). The effective rate (RR) was 62.5%. After 10 cases of liver pain and swelling, 6 cases disappeared completely, 2 cases relieved obviously, and 2 cases had no obvious change. 11 cases of AFP positive, returned to normal in 4 cases, 2 cases decreased significantly, 5 cases no change. Imaging changes: the tumor shrinks, the density of uneven, see liquefied tumor area. Histological changes: liquefied and necrotic tumor tissue, cancer cell degeneration, vascular occlusion, varying degrees of fibrous tissue proliferation. This group of patients with mild side effects, no serious adverse reactions. Conclusion CT-guided interventional treatment of liver cancer is simple and safe. Pirarubicin has a significant therapeutic effect on liver cancer and has mild toxic and side effects.