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目的探讨冠状动脉支架置入术后血清C-反应蛋白(CRP)的变化及其相关因素。方法选择经冠状动脉支架置入术且C-反应蛋白正常的患者54例,监测术前、术后24 h、48 h的情况,术后2周血清C-反应蛋白水平,根据术后CRP水平分为A组(CRP<3.0 mg/L)26例和B组(CRP≥3.0 mg/L)28例,观察6～12个月内主要心血管事件及支架内再狭窄的发生率。结果B组术后6个月内的心血管事件及支架内再狭窄的发生率显著高于A组(P<0.01)。结论冠脉支架置入术后CRP水平的增高与随访期内心血管再发事件及支架内再狭窄发生率相关,提示冠脉支架置入术后血管壁的炎性反应增强是心血管再发事件及支架内再狭窄的主要因素之一。
Objective To investigate the changes of serum C-reactive protein (CRP) after coronary stenting and its related factors. Methods Fifty-four patients with normal C-reactive protein after coronary stenting were enrolled in this study. Preoperative and postoperative 24 h and 48 h postoperative serum C-reactive protein levels were measured. The level of CRP The patients were divided into two groups: group A (CRP <3.0 mg / L) and group B (CRP≥3.0 mg / L). The incidences of major cardiovascular events and in-stent restenosis within 6-12 months were observed. Results The incidence of cardiovascular events and in-stent restenosis within 6 months after operation in group B were significantly higher than those in group A (P <0.01). Conclusions The elevated CRP level after coronary stenting is related to the rate of cardiovascular re-occurrence and in-stent restenosis during the follow-up period. It is suggested that the increased inflammatory reaction in the vessel wall after coronary stenting is a cardiovascular event And stent restenosis one of the main factors.