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目的分析2013~2015年湖北地区虾产品中硝基呋喃类药物的残留情况,以期为硝基呋喃代谢物的来源和危害分析提供科学依据。方法采用超高效液相色谱串联质谱法检测湖北虾产品中呋喃它酮(furaltadone)、呋喃西林(nitrofurazone)、呋喃妥因(nitrofurantoin)和呋喃唑酮(furazolidone)4种硝基呋喃类代谢物的残留量,并用Excel和SPSS 16.0对实验数据进行统计学分析。结果硝基呋喃类药物的代谢产物总体检出率为27.09%,检出的代谢物均为氨基脲(semi carbazide,SEM),河虾的检出率最高,为61.54%;其次是基围虾为6.78%;最低是小龙虾为1.38%;对于整体匀浆的带壳河虾样品,检出率高达91.67%;而去壳的河虾虾肉样品没有检出SEM。结论湖北地区的虾产品中存在不同程度的硝基呋喃污染情况,同时发现河虾中有内源性SEM的存在。结合湖北地区居民的膳食消费情况分析,虾中SEM暴露对人类健康危害较小。
Objective To analyze the residues of nitrofurans in shrimp products in Hubei Province from 2013 to 2015 so as to provide a scientific basis for the analysis of the sources and hazards of nitrofuran metabolites. Methods The residues of furantadone, nitrofurazone, nitrofurantoin and furazolidone metabolites in Hubei shrimp were determined by using ultra performance liquid chromatography-tandem mass spectrometry And SPSS 16.0 for statistical analysis of experimental data. Results The overall detection rate of the metabolites of nitrofurans was 27.09%. The detected metabolites were sem carbazide (SEM). The highest detection rate was 61.54% for shrimp, followed by 6.78 for shrimp %; The lowest was 1.38% for crayfish; the detection rate was as high as 91.67% for the whole homogenized shrimp samples; however, SEM was not detected for the shrimp samples. Conclusion There are different levels of nitrofurans pollution in shrimp products in Hubei Province. At the same time, it is found that there is endogenous SEM in shrimp. Combined with the analysis of dietary consumption of residents in Hubei, SEM exposure in shrimp has less harm to human health.