瘦素通过作用于下丘脑特异受体,具有降低食欲、增加脂肪的氧化消耗从而降低体重的功能。周围组织如肝脏、胰脏、肌肉、血管内皮细胞等都存在瘦素受体。本研究以高脂饲料喂养小鼠,了解瘦素对脂类代谢特别是胆固醇的影响。1　实验方法　将Ｂａｌｂ/ｃ小鼠随机分为正常对照、高脂 Leptin acts on the hypothalamic specific receptors and has the function of reducing the appetite, increasing the oxidative consumption of fat and thus reducing body weight. Leptin receptors are present in surrounding tissues such as liver, pancreas, muscle, and vascular endothelial cells. This study fed mice with high-fat diet to understand the impact of leptin on lipid metabolism, especially cholesterol. 1 Experimental Methods Balb / c mice were randomly divided into normal control, high fat