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目的比较腹腔镜手术与口服克罗米酚(CC)治疗多囊卵巢综合征的临床价值及特点。方法回顾性分析了近年行腹腔镜下卵巢打孔术的28例PCOS患者和口服CC治疗的30例PCOS患者的临床资料,观察其术前、术后激素变化情况以及术后排卵和妊娠情况,并将二者进行对照比较。结果两组患者治疗前后LH、T和LH/FSH值改变差异均有统计学意义(P<0.05);术后FSH值及组间各值比较,差异无统计学意义(P>0.05)。恢复正常月经周期率及排卵率两组比较,差异无统计学意义(P>0.05),但术后妊娠率腹腔镜组(73.08%)显著高于口服CC组(37.93%),差异有统计学意义(P<0.01)。结论腹腔镜下卵巢打孔术治疗PCOS与口服CC治疗PCOS相比更具优越性,对于口服CC治疗疗效不佳或有迫切生育要求的PCOS患者,可选用腹腔镜手术治疗以提高妊娠率。
Objective To compare the clinical value and characteristics of laparoscopic surgery and oral clomiphene citrate in the treatment of polycystic ovary syndrome. Methods The clinical data of 28 PCOS patients undergoing laparoscopic ovarian drilling in recent years and 30 PCOS patients undergoing oral CC treatment were retrospectively analyzed. The changes of hormone before and after surgery, as well as postoperative ovulation and pregnancy, And compare the two for comparison. Results The changes of LH, T and LH / FSH before and after treatment in both groups were statistically significant (P <0.05). There was no significant difference in the value of FSH between groups and between groups after treatment (P> 0.05). There was no significant difference between the two groups in resuming normal menstrual cycle rate and ovulation rate (P> 0.05), but the rate of postoperative pregnancy rate in laparoscopic group (73.08%) was significantly higher than that in oral CC group (37.93%), with statistical difference Significance (P <0.01). Conclusions Laparoscopic ovarian drilling for PCOS is superior to oral administration of PCOS in treating PCOS. For PCOS patients with poor response or urgent need for oral delivery of oral CC, laparoscopic surgery may be used to increase the pregnancy rate.