恶性肿瘤按恶性程度分级的概念,早在十九世纪末期已有萌芽(Hansemann,1893).正式的创导和具体应用当推Broders(1922).他将鳞状细胞癌按癌细胞分化和间变的百分数分为四级,代表由低到高逐步递增的恶性程度. The concept of malignant tumor by grade of malignancy, as early as the late nineteenth Century has been germinated (Hansemann, 1893) .Formal guide and specific applications as a push Broders (1922) .He will squamous cell carcinoma by cancer cell differentiation and The percent change is divided into four levels, representing the degree of malignancy gradually increasing from low to high.