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表观遗传调控是目前国内外研究的热点,其已成为设计治疗多种疾病靶点的重要理论依据。本课题组以表观遗传调控研究为主要脉络,围绕肿瘤中异常的生物学过程,如DNA损伤应答与修复、细胞自噬和代谢等,初步阐明了蛋白质翻译后修饰中的甲基化和乙酰化及其相关的酶类在肿瘤发生发展中的作用及分子机制。现对本课题组的主要原创性工作进行综述与汇报。
Epigenetic regulation is a hot research field at home and abroad, which has become an important theoretical basis for the design and treatment of a variety of diseases. Our research group mainly focuses on the epigenetic regulation of epigenetic regulation. It focuses on the abnormal biological processes in tumors such as DNA damage response and repair, autophagy and metabolism, and initially elucidates the methylation and acetyltransferase And its related enzymes in the development of tumorigenesis and molecular mechanisms. Now the main originality of our work group to review and report.