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目的:探讨卡托普利对日本大耳白兔动脉粥样硬化(AS)及其相关原癌基因c-myc、c-fos变化的影响。方法:将纯种日本大耳白兔随机分成对照组、胆固醇组和不同剂量卡托普利干预组。建立家兔AS模型,观察各组家兔原癌基因c-myc、c-fos变化及大动脉管壁、管腔变化。结果:①高剂量干预组的主动脉管腔面积、内膜/中膜厚度比值、内膜/中膜粥样斑块面积比值在6和12周时均比胆固醇组明显降低(P<0.05,P<0.01),低剂量组与胆固醇组比较差异无统计学意义。②胆固醇组的原癌基因c-mys、c-fos mRNA表达的阳性率较对照组显著增高(P<0.01),而高剂量干预组的阳性率则显著低于胆固醇组(P<0.05),中、低剂量组与胆固醇组比较差异无统计学意义。结论:高剂量的卡托普利能有效防止日本大耳白兔AS形成和发展。
Objective: To investigate the effects of captopril on the changes of atherosclerosis (AS) and its related proto-oncogene c-myc, c-fos in Japanese white rabbits. Methods: Pure Japanese white rabbits were randomly divided into control group, cholesterol group and different doses of captopril intervention group. The rabbit model of AS was established. The changes of c-myc and c-fos proto-oncogene and the changes of the vessel wall and lumen in rabbits were observed. Results: ① The ratio of aortic lumen area, intima / media thickness and intima / media plaque area in high-dose intervention group were significantly lower than those in cholesterol group at 6 and 12 weeks (P <0.05, P < 0.01). There was no significant difference between low dose group and cholesterol group. ② The positive rate of c-myc and c-fos mRNA in the cholesterol group was significantly higher than that in the control group (P <0.01), while the positive rate of the high-dose intervention group was significantly lower than that in the cholesterol group (P <0.05) There was no significant difference between middle and low dose group and cholesterol group. Conclusion: High-dose captopril can effectively prevent AS formation and development in Japanese white rabbits.