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目的研究流感嗜血杆菌(Hi)与婴儿喘息性肺炎的相关性,为婴儿喘息性肺炎合理使用抗生素提供参考依据。方法将500例喘息性肺炎婴儿作为研究对象,治疗前对其进行痰液Hi检测,从而计算出其阳性率,根据药敏结果选择合理抗生素抗感染并评价疗效。结果痰培养标本中婴儿男女喘息性肺炎痰培养Hi阳性率差异无统计学意义(P>0.05);在痰培养Hi呈阳性的病例中,其病情程度不同分为重度、中度、轻度,其Hi的分离株数不同,差异有统计学意义(P<0.05);在婴儿喘息性肺炎痰培养Hi呈现阳性者其住院时间较长达到15 d,而其呈现阴性则只是住院2~5 d,差异有统计学意义(P<0.05)。结论 Hi引起侵袭性疾病与发病季节、月龄有关,与婴儿性别无关,痰培养中Hi的含量与婴儿喘息性肺炎的病情危重程度及预后有相关性,其中Hi含量越高其病情越严重,婴儿喘息性肺炎喘息发作时间长,单纯雾化吸入糖皮质激素效果差,Hi培养率较高。
Objective To study the relationship between Haemophilus influenzae (Hi) and infantile asthmatic pneumonia and to provide a reference for rational use of antibiotics in infantile asthmatic pneumonia. Methods 500 infants with asthmatic pneumonia were selected as subjects. The sputum Hi was detected before treatment, and the positive rate was calculated. According to the susceptibility results, rational antibiotics were selected to resist infection and evaluate the curative effect. Results There was no significant difference in the positive rate of Hi in phlegm culture between infants and children with sputum culture in sputum culture (P> 0.05). In the cases with positive Hi sputum culture, the severity of Hi was different from that in severe sputum, moderate, The number of Hi isolates was different, the difference was statistically significant (P <0.05); in infantile asthmatic pneumonia sputum culture positive Hi were hospitalized for a long time to reach 15 d, while its negative was only hospitalized 2 ~ 5 d, The difference was statistically significant (P <0.05). Conclusion Hi-induced invasive disease is related to the season and age of onset, and has nothing to do with the gender of infants. The content of Hi in sputum culture is correlated with the severity and prognosis of infantile asthmatic pneumonia. The higher the content of Hi, the more serious the condition is. Infant wheezing pneumonia wheezing episodes for a long time, simple inhalation of corticosteroids poor effect, Hi culture rate higher.