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目的探讨高压氧辅助药物三联法治疗急性缺血性脑卒中对患者血清ET-1、CaM及TXB_2水平的影响。方法将206例急性缺血性脑卒中患者随机分为研究组和对照组各10例。研究组给予高压氧联合尤瑞克林、丁苯酞和阿司匹林治疗,对照组给予高压氧联合阿司匹林治疗,2组患者均给予常规治疗,分别在2组患者治疗前后检测血清ET-1、CaM及TXB_2水平。结果治疗前2组血清ET-1、CaM及TXB_2水平比较无显著差异(P>0.05);治疗后2组血清ET-1、CaM及TXB_2水平均较治疗前显著降低(P<0.05),且研究组血清ET-1、CaM及TXB_2水平显著低于对照组,差异均有统计学意义(P<0.05)。结论高压氧辅助药物三联法治疗急性缺血性脑卒中能有效地降低血清ET-1、CaM及TXB_2水平。
Objective To investigate the effects of hyperbaric oxygen-assisted triple therapy on serum levels of ET-1, CaM and TXB_2 in patients with acute ischemic stroke. Methods A total of 206 acute ischemic stroke patients were randomly divided into study group and control group, 10 cases each. The study group was given hyperbaric oxygen combined with norepinephrine, butylphthalide and aspirin. The control group was given hyperbaric oxygen combined with aspirin. The two groups were given routine treatment. The levels of serum ET-1, CaM and TXB_2 level. Results Serum levels of ET-1, CaM and TXB_2 were not significantly different between the two groups before treatment (P> 0.05). The levels of serum ET-1, CaM and TXB_2 in the two groups after treatment were significantly lower than those before treatment (P <0.05) The levels of serum ET-1, CaM and TXB 2 in the study group were significantly lower than those in the control group (P <0.05). Conclusion Hyperbaric oxygen-assisted triple therapy can effectively reduce the levels of ET-1, CaM and TXB_2 in acute ischemic stroke.