目的为阻断经输血传播HIV,提升浙江省血液安全水准。方法自2011年开展阻断经输血传播HIV项目,针对输血过程从血管到血管之不同阶段,采用系统性综合措施,包括前期的加强主动退出与保密性弃血、中期的推广血筛核酸检测和亚甲蓝血浆病毒灭活、后期的推进临床科学合理用血之自体输血。结果项目开展4年来,全省献血者中确认HIV感染快速上升趋势较前被明显遏制(P<0.05),血液核酸筛查覆盖从2011年26.5%至2014年达51.2%,开展血浆病毒灭活工作血站明显增加,75%(9/12)血站其自体输血占临床用血>5%,全省血液安全得以保障。结论阻断经输血传播HIV是一系统性综合举措开展以来全省未见输血感染HIV案例,血液安全水准明显提升。项目成果需持久的维护、推进和创新。 The purpose is to block the spread of HIV by blood transfusion to enhance blood safety standards in Zhejiang Province. Methods Since 2011, the project of blocking the transfusion of HIV through blood transfusion has been carried out. In view of the different stages of blood transfusion from blood vessel to blood vessel, systematic and comprehensive measures were adopted, including the early active withdrawal and confidential abandonment of blood, Inactivated methylene blue plasma virus, the latter part of the rational use of blood transfusions in clinical science. Results In the 4 years since the project was carried out, the rapid increase of HIV infection among blood donors across the province was significantly checked (P <0.05). Blood nucleic acid screening covered 26.5% in 2011 and 51.2% in 2014, and the inactivation of plasma virus Work blood stasis increased significantly, 75% (9/12) of blood transfusions accounted for more than 5% of clinical blood use, the province’s blood safety was guaranteed. Conclusion The prevention of HIV transmission through blood transfusion is a systematic and comprehensive initiative since the province launched a case of HIV infection without blood transfusion and markedly improved its blood safety standards. Project achievements need long-term maintenance, promotion and innovation.