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目的：探讨心理防御机制对2型糖尿病患者血糖的影响。方法对192例2型糖尿病患者（观察组）和100名健康志愿者（对照组）采用一般健康状况‐28、防御方式问卷、状态‐特质焦虑问卷进行心理测试，并进行相关实验室检查。结果两组各量表评分比较差异有显著或极显著性（P＜0.05或0.01）。观察组焦虑症状检出率显著高于对照组（P＜0.01），空腹血糖及糖化血红蛋白均高于正常值。观察组更多地使用不成熟防御方式来降低焦虑，血糖控制不理想。对照组成熟防御方式与皮质醇含量直接相关。结论2型糖尿病患者多存在有不同程度的焦虑情绪，常采用不成熟防御方式，对血糖控制不理想，通过调节患者的防御机制，提高成熟防御方式的应用，对缓解焦虑情绪，调控血糖具有重要作用。“,”Objective To explore the effects of psychological defense mechanism on blood glucose of pa‐tient with type 2 diabetes mellitus (T2DM ) .Methods Psychological tests with the General Health Ques‐tionnaire‐28 (GHQ‐28) ,Defense Style Questionnaire (DSQ) and State‐Trait Anxiety Inventory (STAI) and correlated laboratory examinations were conducted in 192 T2DM patients (observation group) and 100 healthy volunteers (control group) .Results There were significant or very significant group differences in each scale score (P<0.05 or 0.01) .The detection rate of anxious symptoms was significantly higher in observation than control group (P<0.01) ,fasting blood glucose and glycosylated hemoglobin were both higher compared with normal value .Immature defense styles were more used by observation group to low‐er anxiety ,their blood glucose control wasn’t ideal .Mature defense styles were directly related to cortico‐steroid content in control group .Conclusion Most T2DM patients have different degrees of anxious emo‐tion ,often adopt immature defense styles ,blood glucose control isn’t ideal ,and it plays an important pole in relieving anxious emotion and controlling blood glucose to regulate patients ’ defense mechanism and raise the utilizations of mature defense styles .