采用比色法测定尿中内皮源性松弛因子（EDRF）代谢产物——NO2-，结果原发性肾病综合征（肾病）、急性肾小球肾炎（急肾炎）、紫癌性肾炎和慢性肾小球肾炎（慢肾炎）患儿极期显著升高。恢复期或静止期来降至止常。此外，血压升高患儿尿MO2-浓度高、慢性肾炎患儿尿NO2-与血清尿素氮、血清肌酐量成正相关。研究提示肾小球疾病时EDRF产生亢进，该因子不仅介导肾组织损伤，而且还可能导致肾小球内高滤过，促进肾脏病慢性进展。 The urinary endothelium-derived relaxing factor (EDRF) metabolite, NO2-, was measured by colorimetric assay. Results Primary nephrotic syndrome (nephropathy), acute glomerulonephritis (acute nephritis), purple nephritis and chronic kidney Children with glomerulonephritis (chronic nephritis) significantly increased in extreme stage. Convalescence or quiescence to normal. In addition, high blood pressure in children with elevated concentrations of MO2 -, children with chronic nephritis, urinary NO2 - and serum urea nitrogen, serum creatinine was positively correlated. Research suggests that glomerular disease EDRF produced hyperthyroidism, the factor not only mediated renal tissue damage, but also may lead to glomerular hyperfiltration, and promote chronic renal disease progression.