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人类多种肿瘤染色体的 1 0ｑ2 3及其附近存在广泛而频繁的缺失 ,而野生型的 1 0号染色体能较好地抑制如ＧＭＢ细胞在裸鼠中的致瘤性 ,提示 1 0ｑ2 3可能存在抑癌基因[1] 。 1 997年 ,不同的研究小组从 1 0ｑ2 3定位克隆到了ＰＴＥＮ/ＭＭＡＣ1 /ＴＥＰ1 ,其编码的蛋白类似于双
A wide range of frequent and frequent deletions were found in and around the chromosomes of many human tumors, while the wild-type chromosome 10 was able to suppress the tumorigenicity of GMB cells in nude mice, suggesting that 10q23 may exist Tumor suppressor gene [1]. In 1997, different research groups cloned PTEN / MMAC1 / TEP1 from 10q2 3 and encoded a protein similar to the double