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目的探讨大肠腺瘤发生异型增生及癌变的潜在危险因素。方法对发生大肠腺瘤异型增生及癌变的腺瘤大小、解剖部位、外形、病理组织学类型及患者的年龄、性别等因素进行回顾性分析。结果686例大肠腺瘤患者中发生癌变者36例,癌变率为5·3%。年龄≥45岁者与<45岁者大肠腺瘤异型增生程度间差异有显著性意义(P<0·05);不同直径、外形、病理类型的大肠腺瘤的异型增生程度及癌变率间差异有显著性意义(P<0·01);不同部位大肠腺瘤异型增生程度间差异有显著性意义(P<0·01)。结论腺瘤的大小、解剖部位、外形、病理组织学类型及患者年龄是大肠腺瘤异型增生及癌变的潜在危险因素。
Objective To investigate the potential risk factors for dysplasia and carcinogenesis of colorectal adenoma. Methods The size, anatomical location, appearance, histopathological types, age and gender of patients with adenoma of atypia and colorectal adenoma were retrospectively analyzed. Results Among the 686 cases of colorectal adenoma, 36 cases were cancerous and the rate of canceration was 5.3%. There were significant differences in the degree of dysplasia of colorectal adenoma among patients aged 45 years or older and <45 years (P 0.05). The differences in the degree of dysplasia and canceration between colorectal adenomas with different diameter, shape and pathology (P <0.01). There was significant difference in the degree of dysplasia of colorectal adenoma between different sites (P <0.01). Conclusions The size, anatomic location, appearance, histopathology and age of adenoma are potential risk factors for dysplasia and carcinogenesis of colorectal adenoma.