目的:以新方法合成抗癌药卡巴他赛关键中间体7β,10β-二甲氧基-10-脱乙酰巴卡汀Ⅲ。方法:以10-脱乙酰基巴卡汀Ⅲ为原料,选择性在7位、10位羟基引入保护基后,在13位羟基引入不同保护基,然后选择性脱去7位、10位羟基上的保护基,接着在7位、10位羟基上甲基化,后脱去13位保护基,从而得到7β,10β-二甲氧基-10-脱乙酰巴卡汀Ⅲ;经1H-NMR对目标化合物进行验证。结果:经过5步反应合成了7β,10β-二甲氧基-10-脱乙酰巴卡汀Ⅲ,纯度为95%,收率为97%,经验证确定为目标化合物。结论:该合成方法条件温和、操作方便、收率较高,适合大规模生产。 OBJECTIVE: To synthesize 7β, 10β-dimethoxy-10-deacetylbaccatin III, a key intermediate of antitumor drug cabazitaxel by a new method. Methods: The 10-deacetylbaccatin III was used as the starting material to selectively introduce the protective group into the hydroxyl group at the 7-position and the 10-position to introduce different protective groups into the hydroxyl group at position 13, and then selectively remove the hydroxyl group at position 7 and 10 Followed by methylation at the hydroxyl group at the 7-position and the 10-position, followed by deprotection of the 13-position protecting group to give 7β, 10β-dimethoxy-10-deacetylbaccatin III; The target compound is verified. Results: 7β, 10β-dimethoxy-10-deacetylbaccatin Ⅲ was synthesized in 5 steps with a purity of 95% and a yield of 97%. It was confirmed as the target compound. Conclusion: The method has the advantages of mild conditions, convenient operation and high yield, suitable for mass production.