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目的 :观察牛磺酸对实验性大鼠肝纤维化的作用。方法 :用四氯化碳诱导大鼠肝纤维化模型 ,实验分4组 :正常对照组 ,模型对照组 ,牛磺酸高、低剂量组 ,观察大鼠血清丙氨酸氨基转移酶 (ALT)、白蛋白 (Alb)、总胆红素 (TBil)、透明质酸 (HA)、Ⅲ型前胶原 (PCⅢ )、层粘蛋白 (LN)及肝组织中超氧化物歧化酶 (SOD)活性、丙二醛(MDA)含量 ,并观察肝组织病理变化。结果 :牛磺酸治疗组血清ALT、TBil、HA、PCⅢ、LN及肝组织MDA水平显著降低 ,血清Alb及肝组织中SOD活性明显升高 ,肝纤维化程度减轻。结论 :牛磺酸具有抗肝纤维化作用 ,其机制可能与抗脂质过氧化有关
Objective: To observe the effect of taurine on hepatic fibrosis in experimental rats. Methods: The model of hepatic fibrosis induced by CCl4 was divided into four groups: normal control group, model control group, taurine high and low dose groups. The levels of serum alanine aminotransferase (ALT) Alb, TBil, HA, PCⅢ, LN and SOD activity in liver tissue, Dialdehyde (MDA) content, and observe the pathological changes of liver tissue. Results: The levels of serum ALT, TBil, HA, PCⅢ, LN and liver MDA in the taurine treatment group were significantly lower than those in the taurine treatment group. The levels of serum Alb and liver SOD were significantly increased and the degree of liver fibrosis was reduced. Conclusion: Taurine has anti-hepatic fibrosis effect and its mechanism may be related to anti-lipid peroxidation