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目的观察滋肾育胎丸对人流术后患者子宫内膜血管内皮生长因子(VEGF)、雌激素受体(ER)、孕激素受体(PR)表达的影响,探讨滋肾育胎丸对子宫内膜修复的影响机制。方法 69例首次行无痛人流术后患者随机分为两组。对照组自术后两周开始口服维生素E软胶囊,治疗组自术后两周开始口服滋肾育胎丸和维生素E软胶囊。两组均连服14d。两组均经期停药。其后每次月经干净后第1天开始,连服20d,连用2个月经周期。结果治疗组子宫内膜VEGF、PR的表达量均高于对照组(P<0.05);两组之间子宫内膜ER的表达量差异无统计学意义(P>0.05)。结论滋肾育胎丸能促进人流术后子宫内膜VEGF、PR的表达,从而促进生殖功能的恢复。
Objective To observe the effect of Zishen Yutai Pills on expression of endometrial vascular endothelial growth factor (VEGF), estrogen receptor (ER) and progesterone receptor (PR) after abortion, The mechanism of endometrial repair. Methods Sixty-nine patients undergoing first painless abortion were randomly divided into two groups. The control group began oral vitamin E capsules two weeks after operation. The treatment group began oral administration of Zishen Yu fetal pills and vitamin E soft capsules two weeks after operation. Both groups even served 14d. Two groups were menstrual withdrawal. After each menstrual clean after the first day, and even served 20d, once every 2 menstrual cycles. Results The expression of VEGF and PR in the endometrium of the treatment group were significantly higher than those of the control group (P <0.05). There was no significant difference in the expression of endometrial ER between the two groups (P> 0.05). Conclusion Zishenyukantai can promote the expression of endometrial VEGF and PR after abortion, so as to promote the recovery of reproductive function.