过量氟对骨和牙齿的损害非常严重 ,对软骨的损伤也很明显。它可引起软骨细胞坏死和成熟障碍 ,导致软骨蛋白多糖合成与分解失调 ,抑制软骨胶原合成 ,加速软骨胶原分解及改变软骨组织中酶的活性 ,从而破坏软骨。 Excessive fluoride damage to bones and teeth is very serious, the cartilage damage is also very obvious. It can cause chondrocyte necrosis and maturation, resulting in cartilage proteoglycan synthesis and decomposition disorders, inhibition of cartilage collagen synthesis, accelerate the cartilage collagen decomposition and change in cartilage enzyme activity, thus undermining the cartilage.