论文部分内容阅读
Background: This systematic review aims to study the effectiveness of 5-fluorouracil (5FU) in the reduction of tendon adhesions postsurgical repair.Method: A systematic review was performed involving four databases, Cochrane, PubMed, MEDLINE, and Embase, looking for evidence of at least Level I or Level II (according to NHMRC) in the use of 5FU in tendon repairs in human or animal studies. Results: Across the four databases 546 articles were identified. Of these 12 were identified as relevant, with a further two being excluded after in depth review. Conclusions: Nine of the 10 studies showed that 5FU was effective at reducing ten-don adhesions in their respective animal studies. One of the 10 studies showed no significant change compared to the control group.