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目的了解胰岛素样生长因子Ⅰ（ＩＧＦⅠ）在胎儿生长发育中所起的作用。方法选择１７１例产妇及其所分娩的新生儿１６４例，根据出生体重将新生儿分为大于胎龄儿（ＬＧＡ）组：产妇７７例、新生儿６４例；适于胎龄儿（ＡＧＡ）组：产妇５９例、新生儿５９例；小于胎龄儿（ＳＧＡ）组：产妇３５例、新生儿４３例。用放射免疫法测定血清中ＩＧＦⅠ的浓度。结果母血中ＩＧＦⅠ浓度均高于脐血，两者间存在浓度梯度（Ｐ＜０．０１）；母、脐血中ＩＧＦⅠ浓度随孕周增加，至３９～４０周达顶峰；３３～４０周间除ＳＧＡ组外，血中ＩＧＦⅠ浓度与新生儿出生体重呈正相关（ｒ＝０．９１～０．９８）；ＳＧＡ组母、脐血ＩＧＦⅠ浓度与ＡＧＡ组相比，均有不同程度降低（Ｐ＜０．０１）。结论母、儿的ＩＧＦⅠ分泌系统相对独立。ＩＧＦⅠ是调节胎儿生长发育的重要生长因子之一。
Objective To investigate the role of insulin-like growth factor-Ⅰ (IGF-Ⅰ) in fetal growth and development. Methods A total of 171 mothers and 164 newborns were selected. According to the birth weight, newborns were divided into LGA group: 77 maternal and 64 newborn; AGA group : 59 maternal and 59 newborns; SGA group: 35 maternal and 43 newborns. Serum IGF Ⅰ concentration was measured by radioimmunoassay. Results The concentrations of IGFⅠ in maternal blood were higher than that in umbilical cord blood (P <0.01). The concentrations of IGFⅠ in maternal and umbilical cord blood increased with gestational age and reached its peak at 39-40 weeks. 33 ~ 40 weeks in addition to the SGA group, the blood IGF Ⅰ concentration and birth weight was positively correlated (r = 0.91 ~ 0.98); SGA group, umbilical cord serum IGF Ⅰ concentration compared with the AGA group , All decreased to some extent (P <0.01). Conclusion The mother and child IGF Ⅰ secretion system is relatively independent. IGF Ⅰ is one of the important growth factors regulating fetal growth and development.