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目的:了解妊娠晚期外阴阴道假丝酵母菌(vulvovaginal candidiasis,VVC)的发病诱因及相关因素。方法:制定孕期VVC发病情况调查表,对2006年10月～2007年6月行正规产前检查的1 540例晚期妊娠妇女进行问卷调查,常规行糖筛查、糖耐量检查并行阴道分泌物真菌培养,根据结果进行临床分析。结果:晚期妊娠VVC的发病率为34.9%,1 540例孕妇中孕前曾感染过VVC的共354人,占23.0%;孕前曾患VVC的孕妇较未曾感染者孕期发病率明显增高,P<0.01;血糖正常孕妇VVC发生率与血糖异常孕妇VVC发生率比较P<0.05。结论:妊娠前发病史、性生活过频、体重指数过高是孕期VVC的高危因素,妊娠期糖代谢异常者较正常者孕妇VVC发病率明显增加,孕期宜加强预防及治疗。
Objective: To investigate the pathogenesis and related factors of vulvovaginal candidiasis (VVC) in late pregnancy. Methods: To develop a questionnaire on the incidence of VVC during pregnancy. A questionnaire survey was conducted among 1540 late pregnant women who had regular prenatal examination from October 2006 to June 2007. The patients were routinely surveyed with sugar screening and glucose tolerance test for vaginal secretions Culture, according to the results of clinical analysis. Results: The incidence of VVC in advanced pregnancy was 34.9%. There were 354 cases of VVC in 1540 pregnant women before pregnancy, accounting for 23.0%. The pregnant women with VVC before pregnancy had significantly higher incidence of pregnancy during pregnancy than those without VVC (P <0.01) ; The incidence of VVC in pregnant women with normal blood glucose was significantly lower than that in pregnant women with abnormal blood glucose (P <0.05). Conclusion: The history of pre-pregnancy, sexual life over frequency and high body mass index are the risk factors of VVC during pregnancy. The incidence of VVC in pregnant women with abnormal glucose metabolism is significantly higher than that of normal pregnant women. Prevention and treatment should be strengthened during pregnancy.