未折叠或错误折叠蛋白质在内质网腔蓄积及细胞内稳态的破坏将导致内质网应激。适宜的应激有利于细胞内环境的恢复 ,然而严重而持久的内质网应激反应将导致内质网功能受损 ,诱导细胞凋亡。β细胞具有高度发达的内质网 ,是对内质网应激最敏感的细胞之一 ,内质网应激介导的 β细胞凋亡参与了糖尿病的发生。 Failure of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum and destruction of intracellular homeostasis result in endoplasmic reticulum stress. Appropriate stress is conducive to the recovery of the intracellular environment, however, severe and persistent endoplasmic reticulum stress reaction will lead to impaired endoplasmic reticulum and induce apoptosis. Beta cells have highly developed endoplasmic reticulum, which is one of the most sensitive cells to endoplasmic reticulum stress. Endoplasmic reticulum stress-induced beta-cell apoptosis is involved in the pathogenesis of diabetes.