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目的 考查了N甲基双三氟乙酰胺 (MBTFA)衍生化试剂对苯丙胺类毒品的衍生化效果与衍生化条件 ,建立该类毒品三氟乙酰化后的定性定量分析条件。方法 用三氟乙酰化气一质联用分析方法。结果 获得了衍生化产物经气质联用分析后的总离子流色谱图、质谱图及质谱断裂规律 ,以及各种定量参数。结论 经三氟乙酰化后分离效果得到改善 ,且衍生化完全 ,可用于该类毒品的定量分析。
OBJECTIVE To investigate the derivatization and derivatization conditions of amphetamine-type drugs with N-methyl-bistrifluoroacetamide (MBTFA) derivatisation reagent and to establish the qualitative and quantitative analysis conditions of this drug after trifluoroacetylation. Methods Trifluoroacetylation gas with a qualitative analysis method. Results The total ion chromatogram, mass spectrometry and mass spectrometry rupture pattern of the derivatized product were obtained by GC-MS, as well as various quantitative parameters. Conclusion The result of trifluoroacetylation can be improved and its derivatization is complete. It can be used for quantitative analysis of this kind of drugs.