论文部分内容阅读
应用推-挽灌流法和高效液相电-化学检测技术，研究清醒大鼠下丘脑后部5-羟色胺（5-HT）和5-羟吲哚乙酸（5-HIAA）的释放及药物对其释放的影响。结果表明：5-HT的基础释放量为4～15fmol／min，而5-HIAA为50～150fmol／min，高K~+（80、100mmol/L）可依剂量性增加5-HT的释放，对5-HIAA无明显影响，藜芦定（Veratridin，lμmol／L）也有类似的作用,而河豚毒素（Tetrodotoxin，5μmol／L）使其释放减少。
The release of 5-hydroxytryptamine (5-HT) and 5-HIAA in the posterior hypothalamus of awake rats were studied by push-pull irrigation and HPLC-MS. The impact of release. The results showed that the basic release of 5-HT was 4 ~ 15fmol / min and the 5-HIAA was 50 ~ 150fmol / min. The high K ~ + 80,100mmol / L could increase the release of 5-HT in a dose- No significant effect on 5-HIAA, Veratridin (lμmol / L) also had a similar effect, and tetrodotoxin (Tetrodotoxin, 5μmol / L) to reduce its release.