一、肿瘤标志的一般概况肿瘤标志(Tumour Mark,简称瘤标)是指可用一定的方法定性或定量检测,形式上表现多样(蛋白质、抗原、酶、激素或代谢产物等等),与肿瘤相关之物质;它在正常状态下也可能出现,但和肿瘤有质或量的区别。早在1848年,Bence-Jounes发现,检测尿中Bence-Jounes蛋白有助于多发性骨髓瘤的诊断,此乃利用肿瘤标志物的开端。但直到作为肝癌标志的AFP和作为结肠癌标志的CEA的发现才重新引起人们寻找特异性瘤标的兴趣。伴随着 First, the general situation of tumor markers Tumor markers (Tumor Mark) refers to the available qualitative or quantitative detection of certain methods, the performance of a variety of forms (proteins, antigens, enzymes, hormones or metabolites, etc.), and tumor-related The substance; it may also occur under normal conditions, but the qualitative or quantitative difference with the tumor. As early as 1848, Bence-Jounes found that detecting urinary Bence-Jounes protein contributes to the diagnosis of multiple myeloma using the beginning of a tumor marker. However, until the discovery of AFP as a marker of liver cancer and CEA as a marker of colon cancer, the interest of searching for specific tumor markers has not been re-emerged. With it