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对1986年诊断的432例糖耐量减低(IGT)者,于1988年进行复查,IGT每年约7.7％发展为糖尿病(DM)。原空腹及服糖后1、2小时血糖较高的IGT者易发展为DM,可能为长期胰岛素抵抗,胰岛对持续高血糖刺激分泌胰岛素的功能失代偿所致。原血糖较低及控制体重的IGT者易恢复正常,并显示胰岛素抵抗减轻及胰岛素分泌功能改善。IGT者转为DM及正常组后血压降低,可能与血浆胰岛素水平降低有关。
Of the 432 patients with impaired glucose tolerance (IGT) who were diagnosed in 1986, a review was conducted in 1988, with an estimated 7.7% of IGTs developing diabetes mellitus (DM) each year. The former fasting and 1, 2 hours after taking sugar, IGT patients with high blood glucose tends to develop DM, may be long-term insulin resistance, islet hyperinsulinemia caused by sustained insulin secretion due to decompensation. IGT with lower primary blood glucose and weight control returned to normal and showed reduced insulin resistance and improved insulin secretion. IGT into DM and normal group decreased blood pressure, may be related to the reduction of plasma insulin levels.