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目的探讨不同糖耐量状态下血清抵抗素(resistin)与可溶性细胞间黏附分子1(sICAM1)质量浓度的变化。方法2004-04～09在中国医科大学第一临床学院对52例2型糖尿病患者(DM组)、18例糖耐量异常(IGT)组及30例健康对照(NCT)组,采用酶联免疫分析法检测空腹血清resistin及sICAM1质量浓度;同时检测空腹血糖、胰岛素及血脂水平;并以稳态模型计算胰岛素抵抗指数(HOMAIR)。结果IGT组resistin明显高于DM组及NCT组(P均<0.05);DM和IGT组sICAM1均高于NCT组(P<0.01,P<0.05);DM组、IGT组HOMAIR明显高于NCT组(P<0.01)。结论resitin和sICAM1二者可能参与2型糖尿病的发病过程。
Objective To investigate the changes of serum resistin and soluble intercellular adhesion molecule 1 (sICAM1) in different glucose tolerance states. Methods A total of 52 patients with type 2 diabetes mellitus (DM), 18 patients with impaired glucose tolerance (IGT) and 30 healthy controls (NCT) were enrolled in the First Clinical College of China Medical University from April 2004 to December 2009. Enzyme - linked immunosorbent assay Fasting serum resistin and sICAM1 concentrations were measured. Fasting plasma glucose, insulin and lipid levels were measured at the same time. The insulin resistance index (HOMAIR) was calculated by steady-state model. Results The levels of resistin in IGT group were significantly higher than those in DM group and NCT group (all P <0.05). The levels of sICAM1 in DM group and IGT group were significantly higher than NCT group (P <0.01, P <0.05) (P <0.01). Conclusion Both resitin and sICAM1 may be involved in the pathogenesis of type 2 diabetes.