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目的:测定伴或不伴微量白蛋白尿的2型DM患者的血清唾液酸(SA)浓度,以探讨血清SA水平与DM血管病变之间的关系。方法:选75例门诊和住院的2型DM患者,和年龄、性别、体重指数与之相匹配的正常对照者28人。DM患者根据尿白蛋白排泄率分作正常白蛋白尿组和微量白蛋白尿组。测定各组的SA、糖基化血红蛋白、血脂、肌酐。结果:微量白蛋白尿组的SA水平[(631±34)μg/ml]显著高于正常白蛋白尿组[(544±24)μg/ml]和正常对照组,而且正常白蛋白尿组的SA水平亦显著高于正常对照组。结论:血清SA水平增加可能是DM患者心脑血管疾病的危险因子。
OBJECTIVE: To determine the serum sialic acid (SA) levels in type 2 DM patients with and without microalbuminuria to investigate the relationship between serum SA levels and DM vascular disease. Methods: Seventy-two outpatients and hospitalized type 2 DM patients were selected, and 28 healthy controls matched with age, gender and body mass index. Patients with DM were divided into normal albuminuria group and microalbuminuria group according to urinary albumin excretion rate. The SA, glycosylated hemoglobin, blood lipids and creatinine in each group were determined. Results: SA level in microalbuminuria group was significantly higher than that in normal albuminuria group [(541 ± 34) μg / ml) [(541 ± 34) μg / ml) and normal control group SA level was also significantly higher than the normal control group. Conclusion: Increased serum SA may be a risk factor for cardiovascular and cerebrovascular diseases in patients with DM.