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氯吡格雷抵抗的原因很多,包括内源性和外源性机制。药物相互作用可以影响氯吡格雷向活性代谢产物的生物转化。本文就氯吡格雷抵抗与他汀类药物、质子泵抑制剂和红霉素等药物相互作用方面的研究进展进行综述。
There are many reasons for clopidogrel resistance, including both endogenous and exogenous mechanisms. Drug interactions can affect the bioconversion of clopidogrel to the active metabolite. This review summarizes the progress of studies on the interaction of clopidogrel against drugs such as statins, proton pump inhibitors and erythromycin.