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孕晚期胎盘体积与胎儿生长的相关性提示胎盘发育异常可影响胎儿发育。许多证据表明表皮生长因子(EGF)对人类胎盘的发育及其功能具有重要作用。表皮生长因子受体(EGFR)在胎盘中有很强的表达。EGF通过一种具有细胞内酪氨酸激酶决定簇、分子量为170kd的糖蛋白对细胞发挥作用。EGF启动细胞的分裂和分化需要有其受体的磷酸化。胎儿宫内发育迟缓(IUGR)妇女胎盘细胞膜结合EGF的活性可升高或降低。吸烟妇女IUGR的发生率高。曾有报道吸烟妇女胎盘细胞膜EGFR分子量异常且EGF诱导的受体自身磷酸化作用减弱,但未阐明
The correlation between placental volume and fetal growth in late pregnancy suggests that placental dysplasia can affect fetal development. Many evidences indicate that epidermal growth factor (EGF) plays an important role in the development and function of human placenta. Epidermal growth factor receptor (EGFR) is highly expressed in the placenta. EGF acts on cells via a glycoprotein with an intracellular tyrosine kinase determinate and a molecular weight of 170 kd. Fragmentation and differentiation of EGF-primed cells require the phosphorylation of their receptors. Fetal intrauterine growth retardation (IUGR) women’s placental membrane-bound EGF activity can be increased or decreased. Smoking women have a high incidence of IUGR. It has been reported smoking women placental membrane EGFR molecular weight and EGF-induced receptor autophosphorylation weakened, but did not clarify