论文部分内容阅读
目的探讨HBV-DNA定量与不同的HBV模式及肝功能损害指标定量的相关关系。方法收集治疗的235例乙肝阳性患者的血清标本,采用ELISA方法检测HBV标志物及肝功测定。结果 HBV-DNA定量测定显示HBcAg+HBcAb组与小三阳组显著低于大三阳组(P均<0.05),前两者之间差异无统计学意义(P>0.05);HBV-DNA定量在各年龄之间的差异均无统计学意义(P均>0.05),各性别间差异无统计学意义(P>0.05),HBsAg、HBcAg、HBeAg与HBV-DNA呈正相关;HBV-DNA与肝功损害指标PT、AST、ALB、ALT、PAB、TBIL等有一定的相关性。结论 HBV-DNA定量测定结果与HBV模式存在一定的相关性,而HBcAg、HBeAg、HBsAg是乙肝病毒标志物,与其相应的抗体作用,是判断肝功损害的指标之一,HBV-DNA与肝功损害指标有一定相关性,但与年龄、性别无关,针对乙肝患者,应全面检测肝功损害指标以达到诊断和治疗的效用。
Objective To investigate the quantitative relationship between HBV DNA quantification and different HBV modes and indicators of liver dysfunction. Methods Serum samples of 235 patients with positive hepatitis B were collected. HBV markers and liver function tests were detected by ELISA. Results HBV-DNA quantitative analysis showed that HBcAg + HBcAb group and Xiaosanyang group were significantly lower than that of the big Sanyang group (P <0.05), there was no significant difference between the two groups (P> 0.05) There were no significant differences among different age groups (P> 0.05). There was no significant difference between the sexes (P> 0.05). HBsAg, HBcAg and HBeAg were positively correlated with HBV-DNA. HBV- Damage indicators PT, AST, ALB, ALT, PAB, TBIL, etc. have a certain correlation. Conclusion The results of quantitative determination of HBV-DNA have some correlation with HBV model. However, HBcAg, HBeAg and HBsAg are markers of hepatitis B virus, which is one of the indexes to judge the damage of liver function. Damage indicators have some relevance, but with age, sex has nothing to do, for hepatitis B patients, liver function indicators should be fully tested in order to achieve the diagnosis and treatment.