The effect of theophylline on sleep-disordered breathing in patients with stable chronic congestive

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Objective To determine the prevalence of sleep-disordered breathing in patients with stable, optimally treated chronic congestive heart failure and the effect of short-term oral theophylline therapy on periodic breathing in these patients.Methods Patients with stable, optimally treated chronic congestive heart failure were monitored by polysomnography during nocturnal sleep. The effects of theophylline therapy on periodic breathing associated with stable heart failure were observed before and after treatment.Results Patients were divided into two groups. Group Ⅰ (n =21) consisted of individuals with 15 episodes of apnea and hypopnea [as determined by the apnea-hypopnea index (AMI) ] per hour or less; Group Ⅱ (n =15, 41.7%) individuals had an index of more than 15 episodes per hour. In group Ⅱ , the AHI varied from 16. 8 to 78. 8 (42. 6 ±+15. 5) in which the obstructive AHI was 11.1 ± 8. 4 and the central AHI was 31. 5 ±9.6. Group Ⅱ had significantly more arousals (36. 8 ±21. 3 compared with 19.4 Objective To determine the prevalence of sleep-disordered breathing in patients with stable, optimally treated chronic congestive heart failure and the effect of short-term oral theophylline therapy on periodic breathing in these patients. Patients Patients with stable, optimally treated chronic congestive heart failure were monitored by polysomnography during nocturnal sleep. The effects of theophylline therapy on periodic breathing associated with stable heart failure were observed before and after treatment. Results Patients were divided into two groups. Group Ⅰ (n = 21) consisted of individuals with 15 episodes of apnea and hypopnea [as determined by the apnea-hypopnea index (AMI)] per hour or less; Group II (n = 15, 41.7%) individuals had an index of more than 15 episodes per hour. 16. 8 ± 78. 8 (42. 6 ± + 15.5) in which the obstructive AHI was 11.1 ± 8. 4 and the central AHI was 31. 5 ± 9.6. Group II had significantly more arousals (36.8 ± twenty one 3 compared with 19.4
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