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目的探讨抗结核药物肝损害的防治对策。方法回顾分析150例抗结核药物肝损害的病史症状肝功能异常情况及治疗措施和效果。结果肝损害大多发生在化疗前期两个月之内,以中毒性为多见。有肝病史或老年、营养不良、酗酒、缺氧性肺结核等患者抗结核化疗易发生肝损害、根据肝损害和病史采取相应措施保肝治疗大多效果好。结论预防、早期发现及时处理对预后很重要,化疗中要严密观察,定期检测肝功能。
Objective To investigate the prevention and treatment of anti-TB drug liver damage. Methods A retrospective analysis of 150 cases of anti-TB drug-induced liver damage history of liver dysfunction symptoms and treatment measures and results. Results Most of the liver damage occurs within two months before chemotherapy, which is more common with toxic effects. Patients with history of liver disease or elderly, malnutrition, alcoholism, hypoxic pulmonary tuberculosis and other patients prone to liver damage caused by anti-TB chemotherapy, according to liver damage and history to take appropriate measures to protect the liver mostly effective. Conclusion Prevention, early detection and timely treatment of prognosis is very important, chemotherapy should be closely observed, regular testing of liver function.